In 2006,Sano, Shigeki; Kuroda, Yoko; Saito, Katsuyuki; Ose, Yukiko; Nagao, Yoshimitsu published 《Tandem reduction-olefination of triethyl 2-acyl-2-fluoro-2-phosphonoacetates and a synthetic approach to Cbz-Gly-Ψ[(Z)-CFC]-Gly dipeptide isostere》.Tetrahedron published the findings.Formula: C4H8O3 The information in the text is summarized as follows:
(Z)-α-Fluoro-α,β-unsaturated esters I (R1 = ethylcyclopentyl, ethylphenyl, cyclohexyl, tert-Bu, Ph, 2-naphthyl) were stereoselectively prepared by a tandem reduction-olefination of tri-Et 2-acyl-2-fluoro-2-phosphonoacetates II with NaBH4 in EtOH. A concise synthesis of III (Cbz = benzyloxycarbonyl) as a dipeptide isostere was achieved via the tandem reduction-olefination of the corresponding 2-acyl-2-fluoro-2-phosphonoacetate. In the experiment, the researchers used many compounds, for example, Methyl 3-hydroxypropanoate(cas: 6149-41-3Formula: C4H8O3)
Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C4H8O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics