The author of 《Synthesis of the GHIJKL Fragment of Gymnocin-B》 were Sakai, Takeo; Sakakibara, Hideaki; Omoto, Yumi; Tsunekawa, Marina; Hadano, Yoshinori; Kato, Shota; Mori, Yuji. And the article was published in Organic Letters in 2019. Application of 623-47-2 The author mentioned the following in the article:
The GHIJKL fragment (I) of gymnocin-B was synthesized using the oxiranyl anion strategy. The first highlight of the synthesis is the bromoketone cyclization reaction on the oxepane ring to construct the fused bisoxepane GH ring. The second key step is the introduction of the trans-4-hydroxy-3-methyloxepane J ring via addition of trimethylaluminum to a conjugated oxonium moiety, followed by diastereoselective epoxidation and regioselective reduction In the experimental materials used by the author, we found Ethyl propiolate(cas: 623-47-2Application of 623-47-2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Application of 623-47-2
Referemce:
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