Application of 609-08-5In 2020 ,《Novel Pyrimidinone Derivatives Show Anticancer Activity and Induce Apoptosis: Synthesis, SAR and Putative Binding Mode》 appeared in ChemistrySelect. The author of the article were Roy, Ashis; Kundu, Mrinalkanti; Dhar, Pranab; Chakraborty, Arnish; Mukherjee, Soumen; Naskar, Jayatri; Rarhi, Chhanda; Barik, Rajib; Mondal, Susanta Kumar; Wani, Mushtaq Ahmad; Gajbhiye, Rahul; Roy, Kuldeep K.; Maiti, Arup; Manna, Priyadarshi; Adhikari, Susanta. The article conveys some information:
A series of novel bicyclic, substituted pyrimidinone compounds I (R1 = Br, Me, cyclopropyl, etc.; R2 = 4-ClC6H4, cyclohexyl, 1,3-benzothiazol-2-yl, etc.) were designed, synthesized and characterized. In vitro anti-proliferative activity of the synthesized compounds was evaluated against six different human cancer cell lines using MTT assay. Among all twenty four compounds tested, compound II (R3 = Me; R4 = 4-phenylphenyl) exhibited significant cell growth inhibition of human liver cancer cells HepG2 with GIC50 (50% growth inhibitory concentration) value of 120+10 nM and was found to be selective over healthy human embryonic kidney (HEK) cell line (33.1% inhibition at 20μM). Further studies demonstrated that compound II (R3 = Me; R4 = 4-phenylphenyl) induced cell apoptosis in HepG2 cells and resulted in similar effect to Staurosporine, a well known proapoptopic compound widely used to induce apoptosis in various cancer cell lines. Compound II (R3 = Me; R4 = 4-phenylphenyl) also rendered acceptable aqueous solubility (3.5+0.37μM, at pH 7.4) and attractive metabolic stability against human liver microsomes with a half-life of 34.63+0.33 min. Based on the similarity observed between the known tankyrase-1 inhibitors available in literature and compound II (R3 = Me; R4 = 4-phenylphenyl), in silico docking study was performed and the results suggested that the compound interacted with the key amino acid residues present in the tankyrase-1 enzyme active site. After reading the article, we found that the author used Diethyl 2-methylmalonate(cas: 609-08-5Application of 609-08-5)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Application of 609-08-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics