In 2017,Ozdemir, Zulal; Bildziukevich, Uladzimir; Saman, David; Havlicek, Libor; Rarova, Lucie; Navratilova, Lucie; Wimmer, Zdenek published 《Amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid》.Steroids published the findings.Safety of tert-Butyl (5-aminopentyl)carbamate The information in the text is summarized as follows:
A series of amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid with the polyamine spermine and three other diamines, 1,2-diaminoethane, piperazine and cadaverine, were synthesized and their antimicrobial activity and cytotoxicity were investigated. Among the target compounds, several ones showed antimicrobial activity on Gram pos. and Gram neg. microorganisms. The most active compounds had (Streptococcus mutans CCM 7409, 3.125 μM), (Streptococcus mutans CCM 7409, 12.5 μM) and (Escherichia coli CCM 3954, 12.5 μM). In addition, four compounds displayed cytotoxicity on CEM (12.1 ± 2.1 μM, 7.6 ± 1.0 μM, 19.0 ± 0.4 μM and 5.9 ± 0.7 μM, resp.). Two addnl. compounds displayed medium cytotoxicity on CEM, (34.6 ± 5.2 μM) and (37.7 ± 5.9 μM). Two compounds displayed high toxicity also on normal fibroblasts. In addition to this study using tert-Butyl (5-aminopentyl)carbamate, there are many other studies that have used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Safety of tert-Butyl (5-aminopentyl)carbamate) was used in this study.
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Safety of tert-Butyl (5-aminopentyl)carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics