Mino, Takashi; Yamaguchi, Daiki; Kumada, Manami; Youda, Junpei; Saito, Hironori; Tanaka, Junya; Yoshida, Yasushi; Sakamoto, Masami published their research in Synlett in 2021. The article was titled ãChiral P,Olefin Ligands with Rotamers for Palladium-Catalyzed Asymmetric Allylic Substitution Reactionsã?Application In Synthesis of Diethyl 2-methylmalonate The article contains the following contents:
A series of phosphine-olefin-type chiral aminophosphines, was synthesized and confirmed that these each exists as two rotamers at the C(aryl)-N(amine) bond. The ability of these aminophosphines to act as chiral ligands for Pd-catalyzed asym. allylic substitution reactions, such as the alkylation of allylic acetates with malonates or indoles with high enantioselectivities (up to 98% ee) was also investigated. The results came from multiple reactions, including the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Application In Synthesis of Diethyl 2-methylmalonate)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Application In Synthesis of Diethyl 2-methylmalonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics