The author of 《Eco-friendly decarboxylative cyclization in water: practical access to the anti-malarial 4-quinolones》 were Ma, Yue; Zhu, Yongping; Zhang, Dong; Meng, Yuqing; Tang, Tian; Wang, Kun; Ma, Ji; Wang, Jigang; Sun, Peng. And the article was published in Green Chemistry in 2019. Synthetic Route of C7H12O3 The author mentioned the following in the article:
An environmentally benign decarboxylative cyclization in water has been developed to synthesize 4-quinolones I [R1 = H, 6-Me, 7-Br, 5-Cl, etc.; R2 = Me, Ph, Et, etc.; R3 = C(O)OCH2CH3, C(O)OCH2C6H5, C(O)CH3, etc.] from readily available isatoic anhydrides II and 1,3-dicarbonyl compounds R2C(O)CH2R3. Isatins III (R4 = H, 5-Me, 6-Br, 4-Cl, etc.) are also compatible for the reaction to generate 4-quinolones I in the presence of TBHP in DMSO. This protocol provides excellent yields under mild conditions for a broad scope of 4-quinolones I, and has good functional group tolerance. Only un-harmful carbon dioxide and water are released in this procedure. Moreover, the newly synthesized products have also been selected for anti-malarial examination against the chloroquine drug-sensitive Plasmodium falciparum 3D7 strain. Compound I [R1 = H; R2 = 4-C6H5CH2OC6H4; R3 = C(O)OCH2CH3] is found to display excellent anti-malarial activity with an IC50 value of 33 nM. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics