Luo, Xiai; Zhao, Yu; Tao, Susu; Yang, Zhong-Tao; Luo, Hui; Yang, Weiguang published their research in RSC Advances in 2021. The article was titled ãA simple and efficient copper-catalyzed three-component reaction to synthesize (Z)-1,2-dihydro-2-iminoquinolinesã?Electric Literature of C5H6O2 The article contains the following contents:
A operationally simple synthesis of (Z)-1,2-dihydro-2-iminoquinolines I (R = H, F, Cl, OMe; R1 = H, Br, Me, OMe; R2 = Me, Ph, 4-bromophenyl; R3 = n-pentyl, Ph, OEt, i-Pr, OMe, Ot-Bu; R4 = Me, n-Bu, 4-chlorophenyl, etc.) that proceeds under mild conditions is achieved by copper-catalyzed reaction of 1-(2-aminophenyl)ethan-1-ones II, sulfonyl azides R4SO2N3 and terminal ynones R3C(O)CC. In particular, the reaction goes through a base-free CuAAC/ring-opening process to obtain the Z-configured products due to hydrogen bonding. In the experiment, the researchers used many compounds, for example, Ethyl propiolate(cas: 623-47-2Electric Literature of C5H6O2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Electric Literature of C5H6O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics