Luo, Shihui; Weng, Chaoqun; Ding, Yuxuan; Ling, Chen; Szostak, Michal; Ma, Xiaodong; An, Jie published their research in Synlett in 2021. The article was titled ãReductive Deuteration of Aromatic Esters for the Synthesis of α,α-Dideuterio Benzyl Alcohols Using D2O as Deuterium Sourceã?Quality Control of Methyl 4-fluorobenzoate The article contains the following contents:
The first general single-electron transfer reductive deuteration of readily com. available aromatic esters for the synthesis of α,α-dideuterio benzyl alcs. RCH(D2)OH [R = Ph, 4-MeC6H4, 2-FC6H4, etc.] using benign D2O and a mild single-electron donor SmI2 was developed. This operationally convenient method featured very good functional group tolerance and high deuterium incorporations (>95% D2). The potential impact was exemplified by the synthesis of numerous deuterium labeled building blocks of important bioactive compounds Most crucially, the method represented the first example of selective reductive deuteration of benzylic-type ketyl radicals using mild and highly chemoselective lanthanide(II) reagents. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Quality Control of Methyl 4-fluorobenzoate)
Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Quality Control of Methyl 4-fluorobenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics