Reference of tert-Butyl carbamateIn 2021 ,《Asymmetric Total Synthesis of (+)-Quinocarcinamide》 appeared in Organic Letters. The author of the article were Li, Lei; Shi, Li; Wei, Kun; Yang, Yu-Rong. The article conveys some information:
The first asym. total synthesis of (+)-quinocarcinamide I, an enantiomer of the natural oxidation product from antitumor antibiotic (-)-quinocarcin was described. Key steps include an iridium-catalyzed asym. allylic amidation of racemic 1-(2-bromo-6-methoxyphenyl)prop-2-en-1-ol, olefin cross-metathesis followed by a SN2′ to forge tetrahydroisoquinoline II, and stereocontrolled 1,3-dipolar cycloaddition between a facilely generated azomethine ylide IIIand tert-Bu acrylate to construct the diazabicyclo[3.2.1]octane ring IV. In the experimental materials used by the author, we found tert-Butyl carbamate(cas: 4248-19-5Reference of tert-Butyl carbamate)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Reference of tert-Butyl carbamate
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