In 2022,Lekkala, Chinnari; Bodala, Varaprasad; Yettula, Kumari; Karasala, Bharat Kumar; Podugu, Rajitha Lakshmi; Vidavalur, Siddaiah published an article in ACS Omega. The title of the article was 《Copper-Catalyzed One-Pot Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from Arylacetic Acids and Hydrazides via Dual Oxidation》.Electric Literature of C8H7FO2 The author mentioned the following in the article:
A simple and efficient protocol was developed to access sym. and unsym. 2,5-disubstituted 1,3,4-oxadiazoles from arylacetic acids and hydrazides via copper-catalyzed dual oxidation under an oxygen atm. Oxidative decarboxylation of arylacetic acids and oxidative functionalization of the imine C-H bond were the key steps. This was the first example of the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles through dual oxidation in one-pot. Avoidance of the expensive ligand and high yield of the products were advantageous features of the developed method. The results came from multiple reactions, including the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Electric Literature of C8H7FO2)
Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Electric Literature of C8H7FO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics