Kong, Rui’s team published research in Molecules in 2019 | CAS: 4949-44-4

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Computed Properties of C7H12O3

In 2019,Molecules included an article by Kong, Rui; Han, Shuai-Bo; Wei, Jing-Ying; Peng, Xiao-Chong; Xie, Zhen-Biao; Gong, Shan-Shan; Sun, Qi. Computed Properties of C7H12O3. The article was titled 《Highly efficient synthesis of substituted 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) catalyzed by Hf(OTf)4: mechanistic insights into reaction pathways under metal lewis acid catalysis and solvent-free conditionsã€? The information in the text is summarized as follows:

The studies on the catalytic activity of Group IVB transition metal Lewis acids, Hf(OTf)4 was identified as a highly potent catalyst for “”one-pot, three-component”” Biginelli reaction. More importantly, it was found that solvent-free conditions, in contrast to solvent-based conditions, dramatically promoted the Hf(OTf)4-catalyzed formation of 3,4-dihydro-pyrimidin-2-(1H)-ones. To provide a mechanistic explanation, the catalytic effects of Hf(OTf)4 on all three potential reaction pathways in both “”sequential bimol. condensation”” and “”one-pot, three-component”” manners closely examined The exptl. results showed that the synergistic effects of solvent-free conditions and Hf(OTf)4 catalysis not only drastically accelerated Biginelli reaction by enhancing the imine route and activating the enamine route but also avoided the formation of Knoevenagel adduct, which led to an undesired byproduct. In addition, 1H-NMR tracing of the H-D exchange reaction of Me acetoacetate in MeOH-d4 indicated that Hf(IV) cation significantly accelerated ketone-enol tautomerization and activated the β-ketone moiety, thereby contributing to the overall reaction rate. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-oxopentanoate(cas: 4949-44-4Computed Properties of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Computed Properties of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics