《Introducing an α-Keto Ester Functional Group through Pt-Catalyzed Direct C-H Acylation with Ethyl Chlorooxoacetate》 was published in ACS Omega in 2020. These research results belong to Javed, Erman; Guthrie, Jacob D.; Neu, Justin; Chirayath, George S.; Huo, Shouquan. Category: esters-buliding-blocks The article mentions the following:
Platinum-catalyzed selective C-H acylation of 2-aryloxypyridines with Et chlorooxoacetate provided an efficient way of introducing an α-keto ester functional group. The reaction is oxidant-free, additive-free and more significantly free of any decarbonylative side reactions. The reaction tolerated a variety of substituents from strongly electron-donating to strongly electron-withdrawing groups. Double acylation was feasible for 2-phenoxypyridine and its derivatives with only one substituent at the para position. Although the reaction of 2-(2-methylphenoxy)pyridine with Et malonyl chloride did not produce the desired β-keto ester, the reaction with Et succinyl chloride proceeded smoothly to give the γ-keto ester. Et chlorooxoacetate was much more reactive than Et succinyl chloride in this Pt-catalyzed C-H acylation reaction. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Category: esters-buliding-blocks)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics