In 2020,Green Chemistry included an article by Hu, Deqing; Yang, Lu; Wan, Jie-Ping. Computed Properties of C7H13NO2. The article was titled 《Biaryl and atropisomeric biaryl aldehyde synthesis by one-step, metal-free benzannulation of aryl enals and propiolates》. The information in the text is summarized as follows:
A new method involving the benzannulation of aromatic enals ArCH=CHCHO (Ar = C6H5, 2-furyl, 1-naphthyl, etc.) and two alkyl propiolate mols. CHCC(O)2R (R = Me, Et, t-Bu) has been developed as a powerful route to biaryl aldehydes I simply via the promotion of di-Me amine. The benzannulation process in the absence of an oxidant additive tolerates successfully the formyl group in the enal component, leading to a straightforward one-step synthesis of biaryl and atropisomeric aldehydes I. An enamine activation based on the aza-Michael addition of di-Me amine to the propiolate and the amine elimination-based generation of cyclohexadiene intermediate constitute the major factors enabling the titled reactions. In the experimental materials used by the author, we found Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Computed Properties of C7H13NO2)
Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Computed Properties of C7H13NO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics