In 2022,He, Jin-Yu; Qian, Wei-Feng; Wang, Yan-Zhao; Yao, Chaochao; Wang, Nana; Liu, Huilin; Zhong, Bing; Zhu, Cuiju; Xu, Hao published an article in Green Chemistry. The title of the article was 《Sustainable electrochemical dehydrogenative C(sp3)-H mono/di-alkylations》.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate The author mentioned the following in the article:
Catalyst-free, direct electrooxidative phenol derivatives C(sp3)-H mono- and di-alkylation reaction were developed. In contrast to previous typical oxidative and electrochem. coupling, this electrosynthetic approach enabled selective mono- and di-alkylations through metal- and external oxidant-free mild conditions via easily available electrodes. Advances of this strategy were proven by an unparalleled broad substrate scope for efficient C-C, C-N, C-O bond formation as well as excellent site- and regioselectivity. The electrochem. selective alkylations were devoid of addnl. electrolytes, could be conducted on a gram scale, and provided the enone products by cascade electrooxidative dehydrogenation, which highlight a notable potential for further late-stage diversification. Detailed mechanistic studies allowed to delineate the exact profile of the generation of the mono- and di-alkylation events. After reading the article, we found that the author used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics