Formula: C4H8O3In 2008 ,《1ynthesis of an isomeric mixture (24RS,25RS) of sodium scymnol sulfate》 was published in Steroids. The article was written by Harney, Donald W.; Macrides, Theodore A.. The article contains the following contents:
This is the first reported multistep synthesis of the shark bile sterol sodium scymnol sulfate epimeric at the C(24) hydroxyl and C(27) sulfate positions. The starting cholate was protected as tetrahydropyran ether (THP), reduced to the C(24) alc., and oxidized to the protected aldehyde. This aldehyde was then coupled with HO(CH2)2CO2Me using 2 equiv LiNEt2 at -65° to produce (24RS,25RS)-24,27-dihydroxy-3α,7α,12α,tris[(tetrahydropyran-2-yl)oxy]-5β-cholestan-26-oate. After protecting the 24 and 27 hydroxyls as THP derivatives, this fully protected ester was then reduced to the mono-alc. The mono-alc. was sulfated using SO3.NEt3 in DMF. The THP groups were removed with methanolic HCl, and the sulfate was converted to the Na salt with NaOEt in MeOH. This general synthetic scheme has application to produce a range of monosulfated sterols. After reading the article, we found that the author used Methyl 3-hydroxypropanoate(cas: 6149-41-3Formula: C4H8O3)
Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C4H8O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics