《Direct Synthesis of Vicinal Tricarbonyl Amides by Coupling of α-Oxo Acid Chlorides with Carbamoylsilanes》 was written by Han, Yuling; Li, Yuping; Han, Shenghua; Zhang, Pengpeng; Chen, Jianxin. Formula: C4H5ClO3This research focused onvicinal tricarbonyl amide preparation; oxo acid chloride carbamoylsilane cross coupling reaction. The article conveys some information:
A convenient synthetic method for vicinal tricarbonyl amides R(CO)3N(R1)(R2) (R = Me, Ph, OEt; R1 = Me, Bn, n-Pr; R2 = Me, CH2OCH3, 1-phenylethyl) by the cross-coupling reaction of α-oxo acid chlorides RC(O)C(O)Cl with carbamoylsilanes Si(CH3)3C(O)N(R1)(R2) is developed. The reaction tolerates a broad range of substituents on the amido nitrogen of carbamoylsilanes, and directly affords good yields of vicinal tricarbonyl amides under mild conditions without use of oxidants. The reaction of carbamoylsilanes with oxalyl chloride has also been explored, and is accompanied by decarbonylation to give vicinal tricarbonyl amides N(R1)(R2)(CO)3N(R1)(R2) (R1 = Me, R2 = Me, 1-phenylethyl). After reading the article, we found that the author used Ethyl oxalyl monochloride(cas: 4755-77-5Formula: C4H5ClO3)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C4H5ClO3
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics