《γ-Selective Vinylogous Aza-Morita-Baylis-Hillman Reaction with N-Carbamoylimines》 was written by Gondo, Naruhiro; Tanigaki, Yusuke; Ueda, Yoshihiro; Kawabata, Takeo. Category: esters-buliding-blocks And the article was included in Synlett in 2020. The article conveys some information:
Vinylogous aza-Morita-Baylis-Hillman (aza-MBH) reactions of 3-vinylcyclopentenone with N-Boc imines RCH=NC(O)OC(CH3)3 (R = Ph, pyridin-3-yl, 3-chlorophenyl, etc.) provide the corresponding γ-adducts RCH(NHC(O)OC(CH3)3)C(=CH2)R1 (R1 = 3-oxocyclopent-1-en-1-yl) in high regioselectivity (10 examples). While the corresponding reactions with N-Ts imines such as 4-methyl-N-(phenylmethylidene)benzene-1-sulfonamide give the α-adducts such as N-[(2-ethenyl-5-oxocyclopent-1-en-1-yl)(phenyl)methyl]-4-methylbenzene-1-sulfonamide and γ-adducts depending on the catalyst, those with N-Boc imines proceed in a γ-selective manner, irresp. of the promoter. The nature of the protecting groups on the nitrogen of aldimines is found to play a key role in the regiochem. course of vinylogous aza-MBH reactions. The results came from multiple reactions, including the reaction of tert-Butyl carbamate(cas: 4248-19-5Category: esters-buliding-blocks)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Category: esters-buliding-blocks
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