Safety of Ethyl 3-(dimethylamino)acrylateOn November 5, 2021 ,《Visible-Light-Driven Multicomponent Cyclization by Trapping a 1,3-Vinylimine Ion Intermediate: A Direct Approach to Pyrimido[1,2-b]indazole Derivatives》 appeared in Organic Letters. The author of the article were Geng, Xiao; Xu, Zhaoliang; Cai, Yiwen; Wang, Lei. The article conveys some information:
Here a novel visible-light-driven three-component cyclization by trapping an 1,3-vinylimine ion intermediate for the direct synthesis of pyrimido[1,2-b]indazole derivatives from bromodifluoroacetic acid derivatives, enaminones, and 3-aminoindazoles under mild conditions was developed. Notably, the robust methodol. provided a valuable opportunity for the introduction of aliphatic substituents and enables good compatibility of complex bioactive mols. Furthermore, this was the first example of photoinduced multicomponent reaction by employing bromodifluoroacetic acid derivatives as a C1-synthon. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Safety of Ethyl 3-(dimethylamino)acrylate)
Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of Ethyl 3-(dimethylamino)acrylate
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