In 2022,Gatera, Tharcisse; Zhuang, Daijiao; Yan, Rulong published an article in Synlett. The title of the article was 《One-Pot, Catalyst-Free Synthesis of Nitriles from Aldehydes Using Aminating Reagent MsONH3OTf》.Recommanded Product: N-tert-Butoxycarbonylhydroxylamine The author mentioned the following in the article:
An eco-friendly protocol to synthesize nitriles RCN (R = naphthalen-2-yl, n-hexyl, 4-bromophenyl, etc.) from their corresponding aromatic and aliphatic aldehydes RCHO in excellent yields has been developed. This is a catalyst-free protocol which employs an aminating reagent (MsONH3OTf) under mild conditions. The hydroxylamine triflic acid salts (MsONH3OTf) acted as the N source for this protocol. The protocol proved to be easy to perform and presented good functional group tolerance.N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Recommanded Product: N-tert-Butoxycarbonylhydroxylamine) was used in this study.
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Recommanded Product: N-tert-Butoxycarbonylhydroxylamine
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics