The author of 《Rh(III)-catalyzed annulation of Boc-protected benzamides with diazo compounds: approach to isocoumarins》 were Dong, Guangyu; Li, Chunpu; Liu, Hong. And the article was published in Molecules in 2019. Safety of Ethyl 3-oxopentanoate The author mentioned the following in the article:
Isocoumarins I [R1 = H, 6-F, 7-Cl, etc.; R2 = Me, i-Pr, 4-MeOC6H4, etc.; R3 = Me, Et, n-Pr, t-Bu, CH2CH=CH2, Bn] were prepared via rhodium-catalyzed C-H activation/annulation of diazo compounds with Boc-protected benzamide substrates. The tert-Bu formylcarbamate group formally served as an oxidizing DG using the C-N bond as an internal oxidant. In this strategy, the novel Boc-amide groups as removable directing groups enabled the benzamides to construct C-C/C-O bonds to provide isocoumarins I.Ethyl 3-oxopentanoate(cas: 4949-44-4Safety of Ethyl 3-oxopentanoate) was used in this study.
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Safety of Ethyl 3-oxopentanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics