Product Details of 7524-52-9In 2021 ,《Ribose conversion with amino acids into pyrraline platform chemicals – expeditious synthesis of diverse pyrrole-fused alkaloid compounds》 was published in RSC Advances. The article was written by Cho, Soohyeon; Gu, Lina; In, Ik Joon; Wu, Bo; Lee, Taehoon; Kim, Hakwon; Koo, Sangho. The article contains the following contents:
One-pot conversion of sustainable D-ribose with L-amino acid, Me esters produced pyrrole-2-carbaldehydes 5 in reasonable yields (32-63%) under pressurized conditions of 2.5 atm at 80 °C. The value-added pyrraline compounds 5 as platform chems. were utilized for quick installation of poly-heterocyclic cores for the development of pyrrole-motif natural and artificial therapeutic agents. A pyrrole-fused piperazin-2-one scaffold 6 was prepared by reductive amination of pyrralines 5 with benzylamine. While further cyclization of pyrralines 5 with ethane-1,2-diamine produced pyrrolo-piperazin-2-ones 7 with an extra imidazolidine ring, the reaction with 2-amino alcs. derived from natural L-amino acids, alanine, valine, and phenylalanine, resp. provided pyrrolo-piperazin-2-ones 8, 9, and 10 with oxazolidine as the third structural core. Cell viability and an anti-inflammatory effect of the synthesized compounds were briefly tested by the MTT method and the Griess assay, among which 8h and 10g exhibited significant anti-inflammatory effects with negligible cell toxicity. In the experimental materials used by the author, we found H-Trp-OMe.HCl(cas: 7524-52-9Product Details of 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Product Details of 7524-52-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics