《Nickel-Catalyzed Carbonylation of Secondary Trifluoromethylated, Difluoromethylated and Nonfluorinated Aliphatic Electrophiles with Arylboronic Acids under 1 atm of CO》 was written by Cheng, Ran; Zhao, Hai-Yang; Zhang, Shu; Zhang, Xingang. Product Details of 403-33-8This research focused ontrifluoromethyl alkyl ketone preparation; alkyl halide arylboronic acid carbonylation carbon monoxide nickel catalyst. The article conveys some information:
The nickel-catalyzed carbonylation of aliphatic electrophiles with the most straightforward CO remains challenging. An example of the nickel-catalyzed carbonylation of secondary alkyl halides with arylboronic acids under 1 atm of CO is reported. The reaction exhibits high functional group tolerance and broad substrate scope, including trifluoromethylated, difluoromethylated and difluoroacetylated secondary alkyl iodides and secondary benzyl bromides, providing a general and cost-efficient method to access alkyl ketones, especially -trifluoromethylated alkyl ketones that are of great interest in medicinal chem. Preliminary mechanistic studies reveal that a bimetallic oxidative addition is likely involved in the reaction. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Product Details of 403-33-8)
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Product Details of 403-33-8
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