《Stereodiverse Iterative Synthesis of 1,3-Polyol Arrays through Asymmetric Catalytic Hydrogenation. Formal Total Synthesis of (-)-Cyanolide A》 was written by Che, Wen; Li, Yu-Zhen; Liu, Jin-Chi; Zhu, Shou-Fei; Xie, Jian-Hua; Zhou, Qi-Lin. Quality Control of Methyl 3-oxovalerate And the article was included in Organic Letters on April 5 ,2019. The article conveys some information:
An iterative protocol was developed for highly diastereo- and enantioselective construction of high-order 1,3-polyols via iridium-catalyzed asym. hydrogenation of β-alkyl-β-keto esters. The protocol involves four operations-asym. hydrogenation, hydroxy protection, ester hydrolysis, and C-acylation-and the catalyst loading can be as low as 0.005 mol %. The configurations of all stereogenic centers of 1,3-polyols are controlled by the catalyst. By the use of this protocol, a formal total synthesis of the polyketide cyanolide A was achieved with high diastereoselectivity and enantioselectivity. In the experiment, the researchers used many compounds, for example, Methyl 3-oxovalerate(cas: 30414-53-0Quality Control of Methyl 3-oxovalerate)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Quality Control of Methyl 3-oxovalerate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics