《A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer》 was written by Amedei, Amedeo; Asadzadeh, Fatemeh; Papi, Francesco; Vannucchi, Maria Giuliana; Ferrucci, Veronica; Bermejo, Iris A.; Fragai, Marco; De Almeida, Carolina Vieira; Cerofolini, Linda; Giuntini, Stefano; Bombaci, Mauro; Pesce, Elisa; Niccolai, Elena; Natali, Francesca; Guarini, Eleonora; Gabel, Frank; Traini, Chiara; Catarinicchia, Stefano; Ricci, Federica; Orzalesi, Lorenzo; Berti, Francesco; Corzana, Francisco; Zollo, Massimo; Grifantini, Renata; Nativi, Cristina. Related Products of 51857-17-1 And the article was included in iScience in 2020. The article conveys some information:
The Tn antigen is a well-known tumor-associated carbohydrate determinant, often incorporated in glycopeptides to develop cancer vaccines. Herein, four copies of a conformationally constrained mimetic of the antigen TnThr (GalNAc-Thr) were conjugated to the adjuvant CRM197, a protein licensed for human use. The resulting vaccine candidate, mime[4]CRM elicited a robust immune response in a triple-neg. breast cancer mouse model, correlated with high frequency of CD4+ T cells and low frequency of M2-type macrophages, which reduces tumor progression and lung metastasis growth. Mime[4]CRM-mediated activation of human dendritic cells is reported, and the proliferation of mime[4]CRM-specific T cells, in cancer tissue and peripheral blood of patients with breast cancer, is demonstrated. The locked conformation of the TnThr mimetic and a proper presentation on the surface of CRM197 may explain the binding of the conjugate to the anti-Tn antibody Tn218 and its efficacy to fight cancer cells in mice. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Related Products of 51857-17-1) was used in this study.
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRelated Products of 51857-17-1
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics