《Targeted degradation of CD147 proteins in melanoma》 was published in Bioorganic Chemistry in 2020. These research results belong to Zhou, Zhe; Long, Jing; Wang, Yuan; Li, Ya Yun; Zhang, Xu; Tang, Ling; Chang, Qi; Chen, Zhuo; Hu, Gao Yun; Hu, Shuo; Li, Qian Bin; Peng, Cong; Chen, Xiang. Formula: C11H24N2O2 The article mentions the following:
CD147 is a transmembrane glycoprotein and a member of Ig superfamily, is strongly expressed in melanoma cells. CD147 has a pivotal role in tumor development. Therefore, it is a potential drug target for melanoma. In this article, we report the discovery of the first CD147 protein proteolysis targeting chimeras (PROTACs) derived from the natural product pseudolaric acid B (PAB). The representative compound 6a (I) effectively induced degradation of CD147 and inhibited melanoma cells in vitro and in vivo. 6A could be used as the novel type of anticancer agent or as a part of the mol. biol. research toolkit used in the gain-of-function study of the dynamic roles of CD147 in cancer networks. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Formula: C11H24N2O2)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Formula: C11H24N2O2
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