In 2022,Zhou, Kehan; Wang, Dongjie; Ju, Guodong; Deng, Zefeng; Huang, Pengcheng; Huang, Zhibin; Li, Bao; Zhao, Yingsheng published an article in Organic Letters. The title of the article was 《Ligand-Promoted Fluorinated Olefination of Isatins at the C5 Position via a Palladium Catalyst》.HPLC of Formula: 4755-77-5 The author mentioned the following in the article:
A palladium-catalyzed nondirected fluorinated olefination was developed. The oxalyl amide ligand greatly improved the yield of the reaction. A wide variety of isatin derivatives were well tolerated and yielded the corresponding (fluoroalkenyl)isatins I [R1 = H, 6-Me, 4-Cl, etc.; R2 = CF2CF2Br, CO2CH2CF3, C6F5, etc.; R3 = Me, Et, n-Pr, i-Pr; X = O, N(OMe), N(Ot-Bu)] in moderate to good yields. Various fluorinated olefins were also compatible. The application and synthesis of bioactive compounds such as a Metisazone derivative highlighted the synthetic value of this approach. After reading the article, we found that the author used Ethyl oxalyl monochloride(cas: 4755-77-5HPLC of Formula: 4755-77-5)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 4755-77-5
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