In 2022,Zheng, Fuqiang; Zhou, Jianhui; Fang, Feifei; Li, Jiyuan; Wang, Jing; Zheng, Miao; Liu, Hong; Xu, Yungen; Zhou, Yu published an article in Organic Letters. The title of the article was 《Rh(III)-Catalyzed C-H Activation and [4+1+1] Sequential Cyclization Cascade to Give Highly Fused Indano[1,2-b]azirines》.Synthetic Route of C7H12O3 The author mentioned the following in the article:
A Rh(III)-catalyzed C-H activation of α-keto oximes and a cyclization cascade with diazo compounds were developed to construct the highly fused indano[1,2-b]azirine frameworks in good yields with a broad range of substrates under mild reaction conditions. More intriguingly, a [4+1+1] sequential annulation cascade was demonstrated for the first time in this reaction and opened a new reaction mode for α-keto oximes. These fused indano[1,2-b]azirine derivatives could also be further transformed into intriguing privileged drug scaffolds. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3
Referemce:
Ester – Wikipedia,
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