《Highly Enantioselective Construction of Fully Substituted Stereocenters Enabled by In Situ Phosphonium-Containing Organocatalysis》 was published in ACS Catalysis in 2020. These research results belong to Zhang, Hongkui; Jiang, Chunhui; Tan, Jian-Ping; Hu, Hui-Lin; Chen, Yayun; Ren, Xiaoyu; Zhang, Hong-Su; Wang, Tianli. Recommanded Product: Ethyl 3-oxopentanoate The article mentions the following:
We present, herein, an important and practical class of bifunctional in situ phosphonium-containing organocatalysis and its initial application in highly efficient and enantioselective construction of N-containing fully substituted stereocenters through an asym. decarboxylative transformation between cyclic ketimines and β-keto acids. With this catalytic protocol, a variety of optically active cyclic tertiary amine derivatives were readily synthesized in high yields with excellent enantioselectivities (99.0 to >99.9% ee) under very low catalyst loading (0.5 mol %). The success of gram-level preparation and synthetic transformations proves the potential of this catalytic strategy for practical applications. Mechanistic investigation, including control experiments, in situ NMR anal., and ESI-HRMS characterization of intermediates, provides insights into the mechanism. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: Ethyl 3-oxopentanoate)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: Ethyl 3-oxopentanoate
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