Yuan, Feipeng; Hou, Zhen-Lin; Pramanick, Pranab K.; Yao, Bo published their research in Organic Letters on December 6 ,2019. The article was titled 《Site-selective modification of α-amino acids and oligopeptides via native amine-directed γ-C(sp3)-H arylation》.COA of Formula: C8H17NO2 The article contains the following contents:
Site-selective modification of chem. and biol. valuable α-amino acids and peptides is of great importance for biochem. study and pharmaceutical development. Few methods based on remote C(sp3)-H functionalization of aliphatic side-chains of peptides has been disclosed in recent years. In this report, we developed a novel approach for γ-C(sp3)-H and γ-/δ-C(sp2)-H arylation of α-amino acids with α-hydrogen by native amine-directed C-H functionalization and further realized the γ-C(sp3)-H arylation of N-terminally unprotected peptides. In the part of experimental materials, we found many familiar compounds, such as Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2COA of Formula: C8H17NO2)
Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters. Esters are more polar than ethers but less polar than alcohols. COA of Formula: C8H17NO2 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics