Formula: C12H15ClN2O2In 2020 ,《A facile synthesis of meta- and para-terphenylglyoxamide-based peptidomimetics》 was published in Tetrahedron Letters. The article was written by Yu, Tsz Tin; Bhadbhade, Mohan; Kuppusamy, Rajesh; Black, David St. C.; Kumar, Naresh. The article contains the following contents:
A series of meta- and para-terphenylglyoxamide peptidomimetics have been synthesized by the ring-opening of 5-(biphenylyl)-N-acylisatins with alcs., amines and amino acid Me esters. The starting 5-(biphenylyl)isatins were synthesized via the Suzuki-Miyaura coupling reaction in a convenient and efficient manner. In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Formula: C12H15ClN2O2)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Formula: C12H15ClN2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics