Reference of Diethyl 2-methylmalonateIn 2021 ,《Catalytic reductive desymmetrization of malonic esters》 appeared in Nature Chemistry. The author of the article were Xu, Pengwei; Huang, Zhongxing. The article conveys some information:
Here, a dinuclear zinc complex with a tetradentate ligand could selectively hydrosilylate one of the carbonyls of malonic esters to give α-quaternary β-hydroxyesters I [R1 = Me, CH2F, allyl, etc.; R2 = Ph, 3-thienyl, 1-naphthyl, etc.] was reported, providing a promising alternative to the desym. hydrolysis using carboxylesterases. The asym. reduction features excellent enantiocontrol that could differentiate sterically similar substituents and high chemoselectivity toward the diester motif of substrates. Together with the versatile preparation of malonic ester substrates and post-reduction derivatization, the desym. reduction had enabled the synthesis of a diverse array of quaternary stereocenters with distinct structural features. After reading the article, we found that the author used Diethyl 2-methylmalonate(cas: 609-08-5Reference of Diethyl 2-methylmalonate)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Reference of Diethyl 2-methylmalonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics