Wu, Yun; Chen, Annabel W.; Goodnough, Candida L.; Lu, Yao; Zhang, Ye; Gross, Eric R. published an article in 2021. The article was titled 《IcyHot analgesic topical cream limits cardiac injury in rodents》, and you may find the article in Translational Research.Formula: C8H8O3 The information in the text is summarized as follows:
Little is known whether topical analgesic creams, whose natural products enter the blood stream after application, affect myocardial infarct size. Here we tested whether topical analgesic creams can trigger remote cardioprotection and the mechanism involved. Male Sprague Dawley rats were used for an in vivo rodent model consisting of 30 min left anterior descending coronary artery ischemia and 2 h of reperfusion followed by infarct size assessment. The topical analgesic IcyHot, applied to the abdomen prior to ischemia, reduced myocardial infarct size vs. control (41 ± 3* vs 62 ± 1, n= 6/group, *P < 0.001). In contrast, the topical analgesic creams Preparation H, Aspercreme Heat, or Tiger Balm did not alter infarct size. IcyHot, unlike Preparation H, increased circulating Me salicylate levels during reperfusion (3.0 ± 0.6 vs 0.4 ± 0.2 mg/dL, n = 6, *P < 0.001, measured at the internal jugular vein). Me salicylate (10μM) applied to isolated adult cardiac myocytes during reoxygenation reduced cell death when compared to vehicle (21% ± 2%* vs 30% ± 2% of trypan blue pos. cells, n = 9/group, *P < 0.01). Further, treatment with the TRP ankyrin 1 (TRPA1) inhibitors TCS-5861528 (1μM) or AP-18 (1μM) blocked the Me salicylate-induced protective effect in isolated adult cardiomyocytes. In intact rodents, either of the TRPA1 inhibitors (1 mg/kg, i.v.) given prior to IcyHot topical application blocked IcyHot-induced infarct size reduction IcyHot also reduced infarct size when applied 24 h prior to myocardial ischemia or during myocardial ischemia vs. control. Together, these findings support IcyHot analgesic cream can trigger remote cardioprotection through releasing Me salicylate into the bloodstream with cardioprotection occurring by a TRPA1-dependent mechanism. In the experiment, the researchers used many compounds, for example, Methyl Salicylate(cas: 119-36-8Formula: C8H8O3)
Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Formula: C8H8O3
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