In 2022,White, Dawanna S.; Mongeluzi, Daniel; Curry, Alyson M.; Donu, Dickson; Cen, Yana published an article in RSC Advances. The title of the article was 《Facile synthesis of photoactivatable adenosine analogs》.Recommanded Product: N-Boc-1,6-Diaminohexane The author mentioned the following in the article:
Adenosine and its derivatives are important building blocks of the biol. system. They serve as the universal energy currency, amplify intracellular signals for various signal transduction pathways, and can also be used as the co-substrates for enzymic transformations. The synthesis and regulation of adenosine and its analogs rely on the adenosine binding proteins (ABPs). Dysregulated ABP activity contributes to numerous diseases such as cancer, metabolic disorders, and neurodegenerative diseases. Presently, there is intense interest in targeting ABPs for therapeutic purposes. A large fraction of the human ABP family remains poorly characterized. The need for innovative chem. probes to investigate ABP function in the native biol. matrix is apparent. In this study, an adenosine analog, probe 1, with a photoaffinity group and biotin tag was synthesized using concise synthetic strategies. This probe was able to label and capture individual recombinant ABPs with good target selectivity. Probe 1 was also evaluated for its ability to label spiked ABP in complex cell lysates. This chem. probe, together with the labeling and enrichment assay, is of great value to interrogate the biol. functions of ABPs and to elucidate their diversity under different physiol. conditions. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: N-Boc-1,6-Diaminohexane)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRecommanded Product: N-Boc-1,6-Diaminohexane
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Ester – Wikipedia,
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