Quality Control of N-Boc-1,6-DiaminohexaneIn 2020 ,《One-pot thiol-amine bioconjugation to maleimides: simultaneous stabilisation and dual functionalisation》 was published in Chemical Science. The article was written by Wall, Archie; Wills, Alfie G.; Forte, Nafsika; Bahou, Calise; Bonin, Lisa; Nicholls, Karl; Ma, Michelle T.; Chudasama, Vijay; Baker, James R.. The article contains the following contents:
Maleimide chem. is widely used in the site-selective modification of proteins. However, hydrolysis of the resultant thiosuccinimides is required to provide robust stability to the bioconjugates. Herein, we present an alternative approach that affords simultaneous stabilization and dual functionalisation in a one pot fashion. By consecutive conjugation of a thiol and an amine to dibromomaleimides, we show that aminothiomaleimides can be generated extremely efficiently. Furthermore, the amine serves to deactivate the electrophilicity of the maleimide, precluding further reactivity and hence generating stable conjugates. We have applied this conjugation strategy to peptides and proteins to generate stabilized trifunctional conjugates. We propose that this stabilization-dual modification strategy could have widespread use in the generation of diverse conjugates. In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Quality Control of N-Boc-1,6-Diaminohexane)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Quality Control of N-Boc-1,6-Diaminohexane
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