In 2019,Organic Letters included an article by Shao, Xiaoqing; Zheng, Yue; Tian, Lifang; Martin-Torres, Inmaculada; Echavarren, Antonio M.; Wang, Yahui. Application In Synthesis of tert-Butyl carbamate. The article was titled 《Decarboxylative Csp3-N Bond Formation by Electrochemical Oxidation of Amino Acids》. The information in the text is summarized as follows:
Decarboxylative Csp3-N coupling reactions have been developed through electrochem. oxidation of amino acids. The reaction proceeds via anodic oxidative decarboxylation of carboxylic acids to form stabilized carbocations, which are trapped by azoles or amides to construct C-N bonds. This method avoids the preactivation of carboxylic acids and the use of expensive transition-metals and external chem. oxidants. In addition to this study using tert-Butyl carbamate, there are many other studies that have used tert-Butyl carbamate(cas: 4248-19-5Application In Synthesis of tert-Butyl carbamate) was used in this study.
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application In Synthesis of tert-Butyl carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics