《Enantioselective α-Amination of Acyclic 1,3-Dicarbonyls Catalyzed by N-Heterocyclic Carbene》 was published in Organic Letters in 2020. These research results belong to Santra, Surojit; Maji, Ujjwal; Guin, Joyram. Quality Control of Diethyl 2-methylmalonate The article mentions the following:
Herein, we describe a method for the catalytic enantioselective α-amination of α-substituted acyclic 1,3-ketoamides and 1,3-amidoesters that affords the products possessing N-substituted quaternary stereocenters with a chiral N-heterocyclic carbene (NHC). The reaction is based on the utilization of an intrinsic Bronsted base characteristic of NHC that enables the catalytic formation of a chiral ion pair comprising the enolate and the azolium ion. A series of challenging open-chain α-substituted 1,3-dicarbonyls are aminated via this method with ee’s of ≤99%. The experimental process involved the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Quality Control of Diethyl 2-methylmalonate)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Quality Control of Diethyl 2-methylmalonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics