《Synthesis of 1,5-Disubstituted Tetrazole via Ugi Azide Reaction: An Asymmetric Induction Approach》 was published in ChemistrySelect in 2017. These research results belong to Santhosh, L.; Nagamangala, Sagar R.; Thimmalapura, Vishwanatha M.; Vommina, Sureshbabu V.. SDS of cas: 59410-82-1 The article mentions the following:
The Ugi-azide reaction of an enantiopure amino acid derived N-terminal (α-isocyanoesters) (S)-CNCH(R1)CO2R2 (R1 = CH2C6H5, Ph; R2 = Me, Et) and C-terminal isocyanides Cbz-protected amino alkyl isocyanides (S)-CNCH2CH(R3)NHCO2CH2C6H5 (R3 = i-Pr, Ph, CH2C6H5), amino acid esters NH2C(R4)CO2Me (R4 = i-Bu, Me, Ph, etc.), aldehydes such as iso-Pr aldehyde, benzaldehyde and TMS-N3 in MeOH:THF solvent system at 50 °C yielded peptidomimetics e.g., I, comprising tetrazole as amide bond isostere. Ugi-azide reaction is an isocyanide based multi-component reaction (IMCR), as a result, change in amino acid derived isocyanides had given structurally diverse products of biol. interest. Good yields of products were obtained after column purification and found to be stable for shelf storage. The present method offers several advantages such as one-pot simple procedure, high yields and easy purification of products. The experimental part of the paper was very detailed, including the reaction process of H-Phg-OEt.HCl(cas: 59410-82-1SDS of cas: 59410-82-1)
H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.SDS of cas: 59410-82-1 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics