《Methods for the Synthesis of Piperazine Derivatives Containing a Chiral Bi-2-naphthyl Moiety》 was published in Synthesis in 2020. These research results belong to Periasamy, Mariappan; Venkanna, Boda; Nagaraju, Miriyala; Mohan, Lakavathu. COA of Formula: C4H5ClO3 The article mentions the following:
Piperazine derivatives containing 1,1′-bi-2-naphthyl moiety were synthesized starting from 2,2′-dimethoxy-1,1′-bi-naphthalene via acylation using Et chlorooxoacetate and subsequent condensation with 1,2-diamines followed by reduction of the corresponding dihydro-2-piperazinone intermediate using the NaBH4/I2 reagent system. The corresponding chiral piperazine derivatives containing bi-2-naphthyl moiety was synthesized by asym. reduction of Et dimethoxy-bi-2-naphthyloxoacetate by chiral oxazoborolidine catalyst prepared in-situ using S-diphenylprolinol (S-DPP), B(OCH3)3 and H3B·THF. The resulting diols were mesylated and cyclized using 1,2-diamines to obtain the corresponding chiral piperazine derivatives The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5COA of Formula: C4H5ClO3)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.COA of Formula: C4H5ClO3
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