Okayama, Toru; Burritt, Andrew; Hruby, Victor J. published an article in Organic Letters. The title of the article was 《4-Alkoxy-2-hydroxybenzaldehyde (AHB): A Versatile Aldehyde Linker for Solid-Phase Synthesis of C-Terminal Modified Peptides and Peptidomimetics》.Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate The author mentioned the following in the article:
A new and versatile 4-alkoxy-2-hydroxybenzaldehyde (AHB) linker for solid-phase syntheses is described. Acylation of the polymer-bound secondary amine obtained from reductive amination of the aldehyde in the AHB linker showed good reactivity. Following acylation of the phenolic OH group, the resulting carboxamide resin was stable to treatment with 95% CF3CO2H (TFA). The O-acyl functional group was removed with 20% piperidine, and the desired compound was cleaved from the resin by TFA treatment. In the experimental materials used by the author, we found Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate)
Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Recommanded Product: Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics