《Continuous-Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex》 was published in ChemSusChem in 2020. These research results belong to Oetvoes, Sandor B.; Kappe, C. Oliver. Recommanded Product: Methyl 4-fluorobenzoate The article mentions the following:
A simple process was developed in which neat borane dimethylsulfide complex (BH3·DMS) was used to reduce various esters RC(O)OR1 (R = C6H5, cyclohexyl, 2-naphthyl, etc.; R1 = CH3, C2H5, C6H5, CH2C6H5) and amides R2C(O)NR3R4 (R2 = H, Me, Ph; R3 = C6H5, 1-naphthyl, CH2C6H5, etc.; R4 = H, Me, Ph) under continuous-flow conditions. Taking advantage of the solvent-free nature of the com. available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E-factors. In addition, with carefully optimized short residence times, the corresponding alcs. RCH2OH and amines R2CH2NR3R4 were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram-scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate) was used in this study.
Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Recommanded Product: Methyl 4-fluorobenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics