Nural, Yahya’s team published research in ChemistrySelect in 2021 | CAS: 623-47-2

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Synthetic Route of C5H6O2

Nural, Yahya; Ozdemir, Sadin; Yalcin, Mustafa Serkan; Demir, Bunyamin; Atabey, Hasan; Ece, Abdulilah; Seferoglu, Zeynel published their research in ChemistrySelect in 2021. The article was titled 《Synthesis, Biological Evaluation, Molecular Docking, and Acid Dissociation Constant of New Bis-1,2,3-triazole Compounds》.Synthetic Route of C5H6O2 The article contains the following contents:

In this study, new bis-1,2,3-triazole derivatives, N,N’-(1,3-phenylene)bis(2-(4-R-1H-1,2,3-triazol-1-yl)acetamide), were synthesized by copper-catalyzed azide-alkyne cycloaddition click chem. in 84-96% yield. A wide range bioactivity screening was performed to determine DNA cleavage, antioxidant, antibacterial and antifungal activities. All of the synthesized bis-1,2,3-triazoles showed excellent DNA cleavage activity and compound I, bearing 2-bromoethyl moiety as a substituent, was almost degraded all of the plasmid DNA. Mol. docking simulations suggest that the synthesized compounds act as minor groove binders of DNA. The antioxidant activities of the bis-1,2,3-triazoles were determined based on the radical scavenging effect of the stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and iron chelating activity. The compounds exhibited effective iron chelating activity at 200 mg/L while showing a moderate ability to scavenge DPPH radical. The compounds exhibited antibacterial activity with a MIC value in the range of 4-128μg/mL. Compound II, bearing cyclohexylmethyl moiety as substituent, exhibited a broad-spectrum antimicrobial activity (both antibacterial and antifungal). Four different acid dissociation constant (pKa) values of each product were determined potentiometrically in 20% (volume/volume) DMSO-water at 25 +/= 0.1°, at an ionic background of 0.1 mol/L of NaCl using the HYPERQUAD program. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2Synthetic Route of C5H6O2) was used in this study.

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Synthetic Route of C5H6O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics