SDS of cas: 623-47-2In 2022 ,《Non-Decarboxylative Ruthenium-Catalyzed Rearrangement of 4-Alkylidene-isoxazol-5-ones to Pyrazole- and Isoxazole-4-carboxylic Acids》 appeared in Organic Letters. The author of the article were Loro, Camilla; Molteni, Letizia; Papis, Marta; Lo Presti, Leonardo; Foschi, Francesca; Beccalli, Egle M.; Broggini, Gianluigi. The article conveys some information:
Non-decarboxylative ruthenium-catalyzed rearrangement of 4-(2-hydroaminoalkylidenyl)- and 4-(2-hydroxyalkylidenyl)-substituted isoxazol-5(4H)-ones with catalytic amounts of [RuCl2(p-cymene)]2, without any additive, afforded pyrazole-4-carboxylic acids I [R1 = Me, Pr, Ph, etc.; R2 = H, Me, Et, etc.; R3 = Ph, CH2Bn, etc.] and isoxazole-4-carboxylic acids I [R1 = Me, Pr, Ph, etc.; R2 = H, Me, Ph, etc.] resp. The presence of an intramol. H-bond in these substrates was the key to divert the classical mechanism toward a ring-opening non-decarboxylative path that was expected to generate a vinyl Ru-nitrenoid intermediate, the cyclization of which afforded the rearranged products I and II. A gram scale protocol demonstrated the synthetic applicability of this transformation. The results came from multiple reactions, including the reaction of Ethyl propiolate(cas: 623-47-2SDS of cas: 623-47-2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.SDS of cas: 623-47-2
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