SDS of cas: 6553-72-6On May 15, 2015 ,《Nickel-Catalyzed Addition-Type Alkenylation of Unactivated, Aliphatic C-H Bonds with Alkynes: A Concise Route to Polysubstituted γ-Butyrolactones》 appeared in Organic Letters. The author of the article were Li, Mingliang; Yang, Yudong; Zhou, Danni; Wan, Danyang; You, Jingsong. The article conveys some information:
Through the nickel-catalyzed chelation-assisted C-H bond activation strategy, the addition-type alkenylation of unreactive β-C(sp3)-H bonds of aliphatic amides with internal alkynes is developed for the first time to produce γ,δ-unsaturated carboxylic amide derivatives [e.g., amide I + PhCCPh → γ,δ-unsaturated amide II (78% optimized, E/Z 1/2.8) using Ni(OAc)2 and PPh3 in i-PrOH/toluene]. The resulting alkenylated products can further be transformed into polysubstituted γ-butyrolactones with pyridinium chlorochromate (PCC) [e.g., III → IV (78%)]. In addition to this study using Ethyl 1-methylcyclopentanecarboxylate, there are many other studies that have used Ethyl 1-methylcyclopentanecarboxylate(cas: 6553-72-6SDS of cas: 6553-72-6) was used in this study.
Ethyl 1-methylcyclopentanecarboxylate(cas: 6553-72-6) is a member of cyclopentanes. Although cyclopentane itself doesn’t have a single highly favoured conformation, a substituent on the cyclopentane ring can upset the balance of strains thereby favouring either the envelope or the half-chair.SDS of cas: 6553-72-6
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