Koehling, Jonas; Kalinovich, Nataliya; Pajkert, Romana; Tverdomed, Sergey N.; Lork, Enno; Wagner, Veit; Roeschenthaler, Gerd-Volker published an article in 2021. The article was titled 《Oxamates as 1,2-Diketone Equivalents: The Effect of Fluorine》, and you may find the article in ChemistrySelect.Quality Control of Ethyl oxalyl monochloride The information in the text is summarized as follows:
In this paper, new fluorinated derivatives were presented, which were synthesized from selected fluorinated primary amines RFNH2 (RF=CH2CF3, CH2CHF2, CH2CF2CH3, CH(CF3)2, CH(CH3)CF3) or their hydrochlorides and Et oxalylchloride. Since oxamates was considered as 1,2 diketones, their properties, geometries, effective charges at oxygen and nitrogen and the pKa values for the N-H grouping were investigated . In two cases, the mol. structures was measured by XRD, observing almost planar arrangement of C2-N1-C3-C4 atoms. The effect of fluorine was discussed and compared with non-fluorinated oxamates. The effective charges were controlled by various alkyl substituents at nitrogen (branched or straight, fluorinated or non-fluorinated) and can open a new field, especially when fluorinated, for multiple applications in material sciences (surfaces) and biochem. systems (enzymes). In the experiment, the researchers used many compounds, for example, Ethyl oxalyl monochloride(cas: 4755-77-5Quality Control of Ethyl oxalyl monochloride)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Quality Control of Ethyl oxalyl monochloride
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