Synthetic Route of C5H6O2In 2021 ,《Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide》 appeared in Molecules. The author of the article were Ivan, Beatrice-Cristina; Dumitrascu, Florea; Anghel, Adriana Iuliana; Ancuceanu, Robert Viorel; Shova, Sergiu; Dumitrescu, Denisa; Draghici, Constantin; Olaru, Octavian Tudorel; Nitulescu, George Mihai; Dinu, Mihaela; Barbuceanu, Stefania-Felicia. The article conveys some information:
A series of new pyrrole derivatives I (R = H, methoxycarbonyl, ethoxycarbonyl; R1 = Bz, methoxycarbonyl, ethoxycarbonyl, (propan-2-yloxy)carbonyl) were designed as chem. analogs of the 1,4-dihydropyridines drugs in order to develop future new calcium channel blockers. The new tri- and tetra-substituted N-arylpyrroles I were synthesized by the one-pot reaction of 1-methyl-3-cyanomethyl benzimidazolium bromide with substituted alkynes RCCR1 having at least one electron-withdrawing substituent, in 1,2-epoxybutane, acting both as the solvent and reagent to generate the corresponding benzimidazolium N3-ylide. The structural characterization of the new substituted pyrroles I was based on IR, NMR spectroscopy as well as on single crystal X-ray anal. The toxicity of the new compounds was assessed on the plant cell using Triticum aestivum L. species and on the animal cell using Artemia franciscana Kellogg and Daphnia magna Straus crustaceans. The compounds showed minimal phytotoxicity on Triticum rootlets and virtually no acute toxicity on Artemia nauplii, while on Daphnia magna, it induced moderate to high toxicity, similar to nifedipine. This research indicates that the newly synthesized pyrrole derivatives are promising mols. with biol. activity and low acute toxicity. The experimental part of the paper was very detailed, including the reaction process of Ethyl propiolate(cas: 623-47-2Synthetic Route of C5H6O2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Synthetic Route of C5H6O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics