In 2019,Organic Letters included an article by Feng, Fang-Fang; Li, Shen; Cheung, Chi Wai; Ma, Jun-An. Application In Synthesis of tert-Butyl carbamate. The article was titled 《Chiral β-Keto Propargylamine Synthesis via Enantioselective Mannich Reaction of Enamides with C-Alkynyl N-Boc N,O-Acetals》. The information in the text is summarized as follows:
Propargylamines are an important class of compounds in organic synthesis and drug discovery, yet the synthesis of chiral β-keto propargylamines remains underdeveloped. Herein, the authors describe a streamlined and general enantioselective Mannich reaction of enamides with C-alkynyl N-Boc N,O-acetals, which serve as readily available C-alkynyl imine precursors, to access a broad range of chiral β-keto N-Boc-propargylamines bearing single stereogenic centers in high yields (up to 98%) and in high enantioselectivities (up to 95% ee). The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5Application In Synthesis of tert-Butyl carbamate)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Application In Synthesis of tert-Butyl carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics