《Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin》 was published in Organic Letters in 2020. These research results belong to Davison, Emma K.; Freeman, Jared L.; Zhang, Wanli; Wuest, William M.; Furkert, Daniel P.; Brimble, Margaret A.. Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate The article mentions the following:
The first total synthesis of the potent antibiotic anthracimycin (I) was achieved in 20 steps. The synthesis features an intramol. Diels-Alder reaction to forge the trans-decalin moiety, and an unprecedented aldol reaction using a complex β-ketoester to provide the tricarbonyl motif. A Stork-Zhao olefination and Grubbs ring closing metathesis delivered the E/Z-diene and forged the macrocycle. The C2 configuration was set with a base-mediated epimerization, providing access to (-)-anthracimycin.Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate) was used in this study.
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate
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