《A direct route to six and seven membered lactones via γ-C(sp3)-H activation: a simple protocol to build molecular complexity》 was written by Das, Jayabrata; Dolui, Pravas; Ali, Wajid; Biswas, Jyoti Prasad; Chandrashekar, Hediyala B.; Prakash, Gaurav; Maiti, Debabrata. Name: Benzyl acrylate And the article was included in Chemical Science in 2020. The article conveys some information:
Lactones comprise a class of valuable compounds having biol. as well as industrial importance. Development of a methodol. to synthesize such mols. directly from readily available materials such as aliphatic carboxylic acid is highly desirable. Herein, synthesis of δ-lactones I (R1 = Me, R2 = Me, Et, n-Pr, n-Bu; R1 = Et, R2 = Et, i-Pr; R = MeO2C, CN, MeSO2, etc.) and ε-lactones II (R1 = R2 = Me; R’ = Me, Et, Ph, etc.) via selective γ-C(sp3)-H activation is reported. The γ-C-H bond-containing aliphatic carboxylic acids R1R2CMeCH2CO2H provide six- or seven-membered lactones depending on the olefin partner (alkene RCH:CH2 or N-R’-maleimide, resp.) in the presence of a palladium catalyst. A mechanistic investigation suggests that C-H activation is the rate-determining step. Further transformations of the lactones have been carried out to showcase the applicability of the present strategy. The experimental part of the paper was very detailed, including the reaction process of Benzyl acrylate(cas: 2495-35-4Name: Benzyl acrylate)
Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Name: Benzyl acrylate
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