《Selective Fragments for the CREBBP Bromodomain Identified from an Encoded Self-assembly Chemical Library》 was published in ChemMedChem in 2020. These research results belong to Catalano, Marco; Moroglu, Mustafa; Balbi, Petra; Mazzieri, Federica; Clayton, James; Andrews, Katrina H.; Bigatti, Martina; Scheuermann, Joerg; Conway, Stuart J.; Neri, Dario. Formula: C10H22N2O2 The article mentions the following:
DNA-encoded chem. libraries (DECLs) are collections of chem. moieties individually coupled to distinctive DNA barcodes. Compounds can be displayed either at the end of a single DNA strand (i. e., single-pharmacophore libraries) or at the extremities of two complementary DNA strands (i. e., dual-pharmacophore libraries). The authors describe the use of a dual-pharmacophore encoded self-assembly chem. (ESAC) library for the affinity maturation of a known 4,5-dihydrobenzodiazepinone ring (THBD) acetyl-lysine (KAc) mimic for the cyclic-AMP response element binding protein (CREB) binding protein (CREBBP or CBP) bromodomain. The new pair of fragments discovered from library selection showed a sub-micromolar affinity for the CREBBP bromodomain in fluorescence polarization and ELISA assays, and selectivity against BRD4(1). In addition to this study using tert-Butyl (5-aminopentyl)carbamate, there are many other studies that have used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Formula: C10H22N2O2) was used in this study.
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Formula: C10H22N2O2
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