In 2022,Brosnan, Robert J.; Ramos, Kimberly; Aguiar, Antonio Jose de Araujo; Cenani, Alessia; Knych, Heather K. published an article in Pharmacology. The title of the article was 《Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate》.Quality Control of Methyl Salicylate The author mentioned the following in the article:
Introduction: Hydrocarbons with sufficient water solubility allosterically modulate anesthetic-sensitive ion channels. Mint extracts L-carvone and Me salicylate water solubility exceeds modulation cutoff values for γ-amino butyric acid type A (GABAA) receptors, N-methyl-D-aspartate (NMDA) receptors, and type-2 voltage-gated sodium (Nav1.2) channels. We hypothesized that mint extracts modulate these channels at concentrations that anesthetize rats. Channels were expressed sep. in frog oocytes and studied using 2-electrode voltage clamp techniques at drug concentrations up to 10 mM. Normalized current effects were fit to Hill equations. Mint compounds were formulated in a lipid emulsion and administered IV to rats. When unresponsive to the tail clamp, rats were exsanguinated, and plasma drug concentrations were measured. Both mint compounds caused concentration-dependent inhibition of all channels except for Me salicylate which inhibited GABAA receptors at low concentrations and potentiated at high concentrations Plasma drug concentrations in anesthetized rats were 7.9 mM for L-carvone and 2.7 mM for Me salicylate. This corresponded to ≥53% NMDA receptor inhibition and ≥78% Nav1.2 channel inhibition by both compounds and 30% potentiation of GABAA receptors by Me salicylate. Conclusion: L-Carvone and Me salicylate allosterically modulate cell receptor targets important to mol. actions of conventional anesthetics at concentrations that also induce general anesthesia in rats. The experimental part of the paper was very detailed, including the reaction process of Methyl Salicylate(cas: 119-36-8Quality Control of Methyl Salicylate)
Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Quality Control of Methyl Salicylate
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